Impaired diffusing-capacity, lower respiratory muscle strength, and lung imaging abnormalities were detected in more than half of the COVID-19 patients in early convalescence phase. No significant correlation between TSS and pulmonary function parameters was found during follow-up visit. Compared with non-severe cases, severe patients showed higher incidence of DLCO impairment (75.6%vs42.5%, p = 0.019), higher lung total severity score (TSS) and R20, and significantly lower percentage of predicted TLC and 6MWD. 28 (49.1%) and 13 (22.8%) patients had PImax and PEmax values less than 80% of the corresponding predicted values. Abnormalities were detected in the pulmonary function tests in 43 (75.4%) of the patients. Thirty-one patients (54.3%) had abnormal CT findings. There were 40 non-severe cases and 17 severe cases. Resultsįifty-seven patients completed the serial assessments. MethodsĪ retrospective study of COVID-19 patients at the Fifth Affiliated Hospital of Sun Yat-sen University were conducted, with serial assessments including lung volumes (TLC), spirometry (FVC, FEV1), lung diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected at 30 days after discharged. This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.
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